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Dr. Dileep Vijayan Group Leader email : [email protected] |
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I perform chemical biology research to propose novel lead molecules majorly for the drug targets in neurodegenerative disorders, uterine fibroids, epigenetics, cancer, and inflammatory-related diseases. I do multiscale computational approaches with x-ray crystallography, and other biophysical methods. |
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Dr. Saritha Francis Post Doctoral Fellow - DHR (Govt. of India) email : [email protected] |
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Uterine fibroids (UF) are the benign muscular tumors that grows on the walls of the uterus during the reproductive age of women and represents a major health burden worldwide. Although UF can be surgically removed through invasive procedures, the recurrence rate is often high. Hence to counter the unmet medical need of noninvasive treatment of UF, we strive to identify, design, and optimize 'specific progesterone receptor modulators' (SPRMs) using distinct multi-layered self-organizing maps, computational and structural biology approaches. |
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Dr. Remya Chandran Research Associate - DBT (Govt. of India) email : [email protected] |
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Being one of the most common types of dementia, Alzheimer's disease (AD) imposes a tremendous social and economic burden on society. AD is irreversibly debilitating and ultimately fatal, and one of the leading causes of death. Due to the scarcity of drugs for the treatment of AD, novel therapeutic agents are highly demanding. In our research we are trying to identify/design novel poly-pharmacological ligands that can inhibit two drug targets in AD namely Acetylcholinesterase and secretory glutaminyl cyclase. |
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Dr. Ajeena George Ayurveda Physician email : [email protected] |
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According to Ayurveda, the unique health fingerprint of each person, i.e., 'Prakriti' is actually responsible for the homeostasis and metabolic activities in the human body. The prakriti defines the physical, mental and emotional features of a person. Accurate Prakriti determination is still an issue and must be improved. Understanding Prakriti in a comprehensive way gives more clues to the pharmacogenomics and will be helpful in designing of personalized medicines through Ayurveda. Hence, we are trying to understand the phenotypic/genotypic connection to prakriti through an interdisciplinary approach. . |
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Ms. Aiswarya PhD Scholar email : [email protected]
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Psychological and physiological consequences of Alzheimer's disease (AD) impart a high socio-economic burden. While diet can have a positive impact on AD pathogenesis, the benefits of spices and their components remain less explored against the AD. We are striving to isolate and characterize active chemical entities from the essential oils of from spices, and establish their binding potential towards drug targets involved AD. We are also investigating the pharmacodynamics of various known active chemical entities from spices using mouse models. |
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Ms. Himasree PhD Scholar email : [email protected] |
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A swift aggregation of proteins into meticulously structured amyloid fibrils, along with the ensuing deposition of these fibrils into tissues, induces inflammation, eventually leading to dysfunction of organs. The formation and deposition of amyloid fibrils is a defining characteristic of numerous neurodegenerative conditions, such as Alzheimer's disease (AD), Parkinson's disease (PD), and others. Amyloid deposits can either be localized or systemic in nature. The systemic fibrils resulting from the protein lysozyme cause a rare form of autosomal dominant hereditary amyloidosis, which commonly manifests as renal impairment, gastrointestinal symptoms, Sicca syndrome, and other related issues. Currently, there are no drugs available to treat lysozyme-induced systemic hereditary amyloidosis. Thus, our objective is to use rational and computational techniques to design or identify small molecule inhibitors against this type of hereditary amyloidosis. |
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Alumni Ms. Devananda R, Manipal University |
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Ms. Nivedita James
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Ms. Preethika Mohandas
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Ms. Taniya, University of Glasgow
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Ms. Girija Shenoy
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